DOE Modelling and Optimization of Tangential Spray Rotogranulation Mechanism
نویسنده
چکیده
The production of the pellets in the pharmaceutical industry generally involves multi-step processing; 1 mixing, 2 wet granulation 3 spheronization 4 drying. Tangential spray rotogranulation is now being considered as an alternative since it combines number of steps into one processing unit thus reduces processing time. This work aimed to development and doe analysis of GPCG125 and optimization using factorial design. The factors consider were 1-Disc Velocity 2-Feeder rate 3-Air Flow Rate 4-Atm Pressure. The pellets were characterized for their physical properties like drug content. The results indicated that Disc velocity has negative effect on drug content while the feeder rate has positive effect.
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